Preliminary results have indicated the concentration dependence of a group of novel water-soluble porphyrins at the 100 μM concentration level were the most effective in the presence of light via MTT assay. These compounds were tested on several cell lines, including tumor-derived cell lines, to assess the variability of the photoxicity between cell types. In this research, the coupling of the porphyrin, 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin, H<sub>2</sub>TPPC, and the novel 3’-amino-4-hydroxychalcone have led to the synthesis of the new porphyrin-chalcone adduct, H<sub>2</sub>TPP-Chalc-OH (I). Preliminary examination of the phototoxicity of (I) may demonstrate the cytotoxicity of the porphyrins and extend the ability of the chalcones to have phototoxic effects.

Synthesis of a novel water soluble porphyrin-chalcone complex

249th National Meeting (2015)

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