The microwave synthesis and characterization of novel amino-substituted chalcones has been carried out. Chalcones are model compounds based on Combrastatin A4, a natural product of the African willow tree. Attempts were then made to couple the novel amino-chalcones to fluorescein isothiocyanate (FITC). The coupling of 3’-amino-4-hydroxychalcone with fluorescein isothiocyanate characterized. The fluorescein-chalcone derivative allows for fluorescence and microscopic detection of whether the chalcones are selectively taken up by cells and perhaps may even provide <i>in vivo</i> clues to the (tubulin) binding location. Finally, the cytotoxicity of these the amino-chalcones and the fluorescein-chalcone materials will be discussed. The cytotoxicity was examined with and without light exposure. The concentration dependence of phototoxicity and whether the phototoxicity of the chalcone materials is due to activation of apoptosis will also be discussed.

Microwave synthesis and cytotoxicity studies of novel amino-substituted chalcones

249th National Meeting (2015)

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