Oxidative stress in biological systems is known to be involved in the development of many diseases such as Alzheimer’s disease, Parkinson’s disease, many cancers, among numerous other disorders and diseases in patients. Oxidative stress in a biological sample is caused by the accumulation of Reactive Oxygen Species, which results in the formation of free radicals and peroxides which can damage and/or have adverse effects on cell function. Our research primarily involves the oxidative stress biomarker Malondialdehyde (MDA), one of the major products of lipid peroxidation in a cell. The goal of our research is to develop a paper-based microfluidic device that is able to colorimetrically determine levels of MDA in a biological sample, specifically in saliva. This will provide a portable and affordable way to easily and accurately determine ones level of oxidative stress without the use of invasive or expensive equipment.

Paper-based device for colorimetric detection of malondialdehyde in biological samples

249th National Meeting (2015)

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