We have recently developed a facile approach to generate α -substituted chalcones.  This methodology allows for the generation of these biologically active compounds and derivatives with little to no purification.   We have successfully expanded the methodology to generate a variety of substituted groups on the α-carbon yielding α-cyano, ester, nitro, and fluoro chalcones.  We will also report our most recent progress by successfully implementing aliphatic substituted species to the methodology.  Additionally, when these synthetic conditions are applied to α-chloro and bromo chalcones, an unexpected oxide product is generated, where an epoxide forms between the chalcones’ α and β carbons.<br/>

Synthesis of α -chalcones and derivatives via a microwave Knoevenagel condensation <br />

249th National Meeting (2015)

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