Formation of PVC membrane sensors using different approaches e.g. ion-pair, ionophore and Schiff-base as sensing membrane will discuss. Analytical applications of membrane sensors for direct measurement of a wide variety of different ions in complex biological and pharmaceutical samples were reported. The vital component of such plasticized PVC membrane is the sensing active material. The potentiometric sensors have some outstanding advantages including simple design and operation, wide linear dynamic range, relative fast response and rational selectivity. The construction and electrochemical response characteristics of Poly (vinyl chloride) membrane sensors for moxifloxacin HCl (MOX) are described. The sensing membranes incorporate ion association complexes of moxifloxacin cation and sodium tetraphenyl borate (NaTPB) (sensor 1), phosphomolybdic acid (PMA) (sensor 2) or phosphotungstic acid (PTA) (sensor 3) as electroactive materials. The sensors display a fast, stable and near-Nernstian response over a relative wide moxifloxacin concentration range (1 ×10-2 - 4.0×10-6, 1 × 10-2 - 5.0×10-6, 1 × 10-2 - 5.0×10-6 M), with detection limits of 3×10-6, 4×10-6 and 4.0×10-6 M for sensor 1, 2 and 3, respectively over a pH range of 6.0 - 9.0. The sensors show good discrimination of moxifloxacin from several inorganic and organic compounds. The direct determination of 400 mg/ml of moxifloxacin show an average recovery of 98.5, 99.1 and 98.6 % and a mean relative standard deviation of 1.8, 1.6 and 1.8% for sensors 1, 2 and 3 respectively. The proposed sensors have been applied for direct determination of moxifloxacin in some pharmaceutical preparations. The results obtained by determination of moxifloxacin in tablets using the proposed sensors are comparable favorably with those obtained using the US Pharmacopeia method. The sensors have been used as indicator electrodes for potentiometric titration of moxifloxacin.

Potentiometric PVC membrane sensors and their analytical applications in pharmaceuticals analysis: One example potentiometric PVC membrane sensors determination of moxifloxacin in pharmaceutical dose form

249th National Meeting (2015)

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