GABAA receptors are an important class of receptors in the brain that are involved in controlling very vital functions. Our lab is engaged in designing subtype selective ligands targeting various receptor subunits of GABA. The present project is directed towards developing ligands that are α6 subtype selective ligands, these cells are present predominantly in the granule cells of the cerebellum, the cochlear nucleus and in the peripheral ganglia1. Ligands of type I have shown promising results. The oocyte and other data will be discussed. 1. Zdravko Varagic, Joachim Ramerstorfer, Shengming Huang, Sundari Rallapalli, Isabella Sarto-Jackson, James Cook, Werner Sieghart and Margot Ernst, British J. Pharmacology (2013), 169(2), 384-399.

Development of α6β3γ2-subtype selective ligands for GABAA receptors

249th National Meeting (2015)

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