we present an AgF-mediated fluorinative cross-coupling between a gem-difluoroolefin and a non-fluorinated olefin. This protocol is highly efficient and provides facile access to both alfa-CF3 alkenes and beta-CF3 ketones which otherwise remain challenging to be directly prepared. The application of this method is further demonstrated in the synthesis of bioactive isoxazoline derivatives. It represents a conceptually novel route that the trifluoromethylated compounds can be achieved via combining the in-situ CF3 generation and the C-H functionalization in a single reaction system.

AgF-mediated fluorinative cross-coupling of two olefins

249th National Meeting (2015)

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