The design and synthesis of water compatible porphyrin nanoparticles (NPs) with enhanced photo-physical properties is emerging as an important research focus because such NPs find potential application in the biomedical field serving as agents for photo dynamic therapy and biological imaging. Furthermore, they are also intriguing building blocks for nano structured devices such as oxygen sensors and photonic systems. In this poster, we described a strategy to construct photo-active porphyrin spherical NPs composed of a supramolecular complex between tetrakis(4-N-methylpyridyl)porphyrin (TMPYP), cucurbit[7]uril (CB[7]), and poly(propylene glycol) monobutyl ether (PPG). TMPYP is a well-known photosensitizer, however, it typically self-stacks in water via aromatic interactions resulting in attenuated photophysical properties. In marked contrast, these TMPYP containing NPs exhibit attenuated porphyrin stacking and thus show enhanced photo-physical properties (in terms of both absorption and fluorescence). These NPs have been characterized by means of TEM, UV-vis spectroscopy, fluorescence spectroscopy, and singlet oxygen generation studies.

Tmpyp containing nanoparticles with enhanced photo –physical properties

249th National Meeting (2015)

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