Analysis has been performed on the pharmaceutical compound promethazine in saline solution under various temperatures, to determine percent conversion of promethazine to its sulfoxide and sulfone upon exposure to oxygen in the atmosphere. Measurements were taken to determine the percent oxidation of promethazine as a function of time by HPLC-MS analysis and UV-VIS spectrophotometric analysis with Beer’s law correlations. Kinetic data established by these analyses were used to determine rate constants (k<sub>r</sub>) calculated from the known rate expressions.

Determining the rate of oxidation of promethazine to its sulfoxide and sulfone in atmospheric O<sub>2</sub> using HPLC-MS and UV-VIS spectrophotometric analysis

249th National Meeting (2015)

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Determining the rate of oxidation of promethazine to its sulfoxide and sulfone in atmospheric O2 using HPLC-MS and UV-VIS spectrophotometric analysis

Determining the rate of oxidation of promethazine to its sulfoxide and sulfone in atmospheric O₂ using HPLC-MS and UV-VIS spectrophotometric analysis