The reaction of creatine with hypochlorous acid is of biological interest.  The absorbance of the reaction mixtures as a function of time has been measured at pH 4, 7, and 10.  The rate of the reaction and the observed spectral changes differ significantly over this range.  A unified mechanism leading to the known product, N-formyl-N-methylglycine, has been proposed. These experimental spectral have been fit using rate constants for the important steps of the mechanism and molar absorptivities of the various proposed intermediates.  Insight into this very complex mechanism are gleaned from the analysis and are the subject of this presentation.

Reaction mechanism for the conversion of creatine to N-formyl-N-methylglycine by hypochlorous acid in aqueous solution

249th National Meeting (2015)

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