Naturally occurring flavonoid compounds have shown great biological potential, in particular the subclass of flavonoids known as aurones. Previous studies have shown that aurones exhibit anti-cancer activity as well as a variety of other pharmacological activities, including anti-inflammatory and anti-viral properties. More specifically, these studies indicate that aurones show potential in inhibiting cyclooxygenase-2 activity (COX-2), which plays an integral part in inflammation and its associated diseases, such as cancer. Mills, et. al. recently performed molecular docking studies of several novel aurones at the COX-2 active site. As a continuation of this research, a synthetic pathway for one of the most promising aurone derivatives, a novel trifluoromethyl-substituted aurone, has been proposed. The final target molecule will be synthesized using this route and the novel compound will be characterized.

Progress toward synthesis of a novel trifluoromethyl substituted aurone as a potential cyclooxygenase-2 inhibitor

249th National Meeting (2015)

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