Derivatives of carba-<i>closo</i>-decaborate(1-) carborane anion (<i>closo</i>-CB9) have potential uses in nuclear medicine, medical imaging, and other pharmaceutical applications. The carbon in the cluster can be functionalized by a variety of groups, making this site an ideal attachment point for proteins and other biomolecules. The boron vertices in CB9 readily undergo iodination to give highly iodinated species that have potential uses as X-ray contrast agents. This strategy could likewise be used with radioiodine or astatine-211 to give useful imaging agents or therapeutic compounds. The preparation of derivatized CB9 clusters and investigations of conditions for efficient halogenation of these clusters will be discussed.

Investigations of the halogenation, radiohalogenation, and functionalization of CB9 carborane clusters

249th National Meeting (2015)

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