Pd-catalyzed cross-coupling reactions have become integral to both academia and industry over that last two decades, although the seminal contributions happed during the 1970’s. These reactions constitute one of the most powerful methods for the formation of C-C and C-heteroatom bonds with direct applications in the synthesis of pharmaceuticals, agrochemicals, materials for electronic devices, and more. At Johnson Matthey, our goal has long been to provide practical yet novel catalysts for these applications on commercial scale, while providing a theoretical understanding behind the structure activity relationship. In this regard, we have developed and introduced many exceptional precatalysts (traditional and new-generation) for several reaction types including Heck, Suzuki-Miyaura, ketone enolate arylation, Sonogashira, Buchwald-Hartwig amination, to name a few for commercial applications. Herein, we will cover the history of the development and implementation of these catalysts from an industrial perspective while understanding the role of academia, covering the past two decades.

<b>Award Address</b> (ACS Award in Industrial Chemistry sponsored by the ACS Division of Business Development & Management and the ACS Division of Industrial & Engineering Chemistry). Story of Pd-catalyzed coupling: The reactions of the 21st century

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Award Address (ACS Award in Industrial Chemistry sponsored by the ACS Division of Business Development & Management and the ACS Division of Industrial & Engineering Chemistry). Story of Pd-catalyzed coupling: The reactions of the 21st century