This research attempted a mass scale-up of workups conducted on a smaller level. The model experiment used 4-methyl cinnamic acid and excess hydrazine under thermal conditions and then a hot vacuum. The experiment was conducted on a 100mmol scale up. Once the scale up was completed successfully. Some <i>N</i>-alkylation tests were conducted during the second scheme of the procedure. Previous experiments have shown this to work with benzaldhyde or benzyl bromide. The procedure was tested with several other alkyl halides in benzyl bromide's stead.

Mass scale-up of pyrazolidinones and <i>N</i>-alkylation tests

249th National Meeting (2015)

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Mass scale-up of pyrazolidinones and N-alkylation tests