Tumorous cancer cells have shown to have elevated levels of polyamine transport systems attached to the cell surface versus normal cells. In order to maintain an effective drug delivery system, we aim to attach polyamines to the nucleic acid base (nucleobase) guanosine. Guanosine is preferred due to its biocompatibility and high magnitude of packed molecules that produce hydrogels. The work developed for this project involves synthesis and protection of polyamines for appendage to functionalized nucleobases. The development of this drug delivery system will allow for the guanosine: polyamine compounds to specifically target cancer cells via the polyamines transport systems.

Drug delivery systems utilizing modified nucleobase hydrogelators and polyamines: Synthesis of polyamines

249th National Meeting (2015)

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