Chalcones and their derivatives are some of the many occurring natural products. They can be found in fruits, vegetables, spices, tea and soy. These compounds are well known for their broad range of biological activities, specifically for their antimalarial, antibacterial, antitumor, antioxidant, and anti-HIV activity. It is known that replacing one of the aromatic rings of a chalcone with a ferrocenyl group results in greater biological activity, presumably due to the lipophilicity of the ferrocenyl group and resulting bioavailability. Some chalcone derivatives are also known to exhibit greater biological activity than their corresponding chalcone core, as is the case for the thiosemicarbazone derivatives. This research is focused on thiosemicarbazone derivatives. We pursue three specific aims: (a) develop an efficient methodology for their synthesis from ferrocenyl chalcones, (b) spectral and electrochemical characterization, and (c) collaborative-based biological testing for malaria and a series of bacteria. The synthetic methodology, characterization and preliminary biological assays of these compounds will be elaborated.

Thiosemicarbazone-derivatives from ferrocenyl chalcones as potential antibacterial and antimalarial agents

249th National Meeting (2015)

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