Synthesis of trifluoromethyled amino acids derived from indole is described. Commercially available starting materials were used as basic building blocks, and the synthesis of proposed compounds was achieved by aminoalkylation of indoles with trifluoromethylated imines to form trifluoromethylated-indole amino esters which on further hydrogenolysis provided the corresponding acids.

Synthesis of indole derived fluorine-containing amino acids

249th National Meeting (2015)

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