We designed a class of helical, cationic charged polypeptides via the ring-opening polymerization of vinyl benzyl glutamic acid <i>N</i>-carboxyanhydrides. These materials have unusual helical stability and display excellent cell penetrating property, outperforming TAT peptide. By controlling the chemical, morphological and self-assembly structures of these side chain charged, helical polypeptides, we identified a few materials that showed excellent gene and siRNA delivery efficiency in vitro and in vivo.

Helical polypeptides mediated nonviral gene and siRNA delivery

249th National Meeting (2015)

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