Selective estrogen receptor modulators (SERMs) are class of compounds heavily utilized in the treatment of breast cancer. Despite their importance, utility is limited by side effects due to unfavorable estrogenic activity in other tissues. An ideal SERM would inhibit mammary carcinogenesis while maintaining positive estrogenic activity in the brain, bone, and fatty tissues. Herein, we report the design and progress towards the synthesis of a novel SERM.

Search for an ideal selective estrogen receptor modulator (SERM)

249th National Meeting (2015)

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