Mass spectrometry can provide a wide range of analytical information on compounds that produce either ions during electrospray ionization (ESI). This project centers on the study of a range of target compounds and the impact of ESI conditions on the observed data. For negative ion mode this research focused on the analysis of the pain relieving drugs. Optimal ionization conditions were determined over a wide range of solution and instrument conditions. For positive ion mode the research focus on the analysis of Polyethylene glycol (PEG) and polypropyleneglycol (PPG) solutions. Samples for each polymer where studied with different complexing cations added (Li+, Na+, K+, Rb+, Cs+, NH4+ and Ag+). Analytes were run at a range of cone voltages to study the impact of each complexing cation on the observed polymer distribution.

Study of the impact of ionization conditions on ion formation in electrospray mass spectrometry

249th National Meeting (2015)

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