Protein dynamics play an important role in molecular recognition and catalysis. Each protein structure has a unique dynamics encoded by its primary sequence. It has been proposed that the protein structure and function are related through its dynamics. Therefore, in an attempt to develop a dynamics-based classification of proteins, the intrinsic dynamics of enzymes involved in primary metabolic pathways are being investigated using coarse-grained normal mode analysis. Herein, we will present the preliminary results of the NMA study of fifteen families of enzymes. The initial results demonstrate that each enzyme family exhibits unique patterns of motions that are conserved across multiple species. Completion of this study is expected to produce a catalog of characteristic dynamics that could be used for functional classification of proteins.

Exploring the intrinsic dynamics of proteins involved in metabolic pathways using coarse-grained normal mode analysis

249th National Meeting (2015)

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