Herbarin A and B were from two strains of the fungus cladosporium herbarum found in sponges aplysina aerophoba and callyspongia aerizusa respectively. Initial biological activity of these natural products was performed on polyphagous pest insect larvae and brine shrimp larvae. As a consequence of their remarkable biological activity and unique chemical structure, we describe a multi-step synthetic route towards Herbarin A and B. This synthetic approach provided target compounds in multi-gram scale quantity, which is not possible from their natural source. We have investigated the anti-oxidant properties of Herbarin A and B and also performed the toxicity assay using zebra fish embryo model.

Total synthesis of Herbarin A and B and determination of their anti-oxidant properties and toxicity in Zebra fish model

249th National Meeting (2015)

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