Translocator protein (TSPO) is an 18 kDa transmembrane protein found in the outer membrane of mitochondria. TSPO has been associated with a variety of diseases and is a potential drug target for heart disease, diabetic neuropathy, cancer, and neurodegeneration. We chose to study TSPO from <i>R. sphaeroides</i> due to its high homology to other species. TSPO from <i>R. sphaeroides</i> is essential for the regulation of photosynthesis. We have focused our studies on ligand binding and potential catalytic activity. Additionally, structural characterization of the protein was performed using NMR spectroscopy.

Structural and functional studies of TSPO

249th National Meeting (2015)

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