Several microRNAs have been linked to the occurrence of cancer and thus the accurate measurement of these short, regulatory sequences could potentially serve as an early marker of disease. We seek to develop an electrochemical sensor to measure relative microRNA levels in normal and diseased cells. Detection of target sequences is evidenced indirectly by the downstream detection of displaced labeled oligonucleotides. Voltammetric and spectroscopic characterization of hybridization events at gold substrates will be presented.

Development of an electrochemical microRNA sensor

249th National Meeting (2015)

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