Naturally occurring beta-sheets are a common structural motif appearing in complex biological molecules. The laboratory synthesis of beta-sheet mimics allows us to isolate and probe their intramolecular hydrogen bonding tendencies. We hope to strengthen the next generation of beta-sheet mimics by optimizing rigidity and hydrogen bonding affinity. The premium placed on these structural attributes can provide a layer of difficulty to the synthetic trajectory. Additionally, smaller control molecules were synthesized that exhibit the potential to form intramolecular hydrogen bonds. These smaller molecules allow us to develop a foundational understanding of the same hydrogen bonding principles that are applied in larger molecules, such as our mimic.

Hydrogen bonding principles and synthetic beta-sheet mimics

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.