Cancer stem cells (CSCs) are a sub-population of cancer cells within tumors possessing self-renew potential and enriched stem cell marker expression. Aldehyde dehydrogenase (ALDH) activity is a cancer stem cell marker in several types of human cancers and is also a major clinical determinant of poor prognosis. Recent reports show an inverse correlation between the number of ALDH+ cancer cells and the expression level of the cyclin-dependent kinase (CDK) inhibitor p27KIP1. In order to better understand the links that exist between p27KIP1 regulation and ALDH expression, we have synthesized and tested a series of modified p27KIP1 promoter-reporters to uncover and target downstream signaling cascades involved in the resistance mechanisms of CSCs.

Modified p27KIP1 promoter-reporters in the context of cancer stem cells

249th National Meeting (2015)

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