Surface functionalization of nanomaterials is an area of current investigation that supports the development of new biomaterials for applications in biology and medicine. Herein, we describe the synthesis, characterization, and antibacterial properties of the first examples of graphite nanofibers (GCNFs) that have been covalently functionalized with aminoglycoside and quinolone antibiotics. Ruthenium tetroxide oxidation of herringbone GCNFs gave higher amounts of surface carboxyl groups than previous methods. These carboxyl groups served as sites of attachment for antibiotics by acyl substitution. Bioassay of these novel, functionalized GCNFs using serial dilution and optical density methods demonstrated that antibiotic-labeled GCNFs possess antibacterial activity against Pseudomonas aeruginosa. The acitivity we observe for aminoglycoside-functionalized GCNFs suggests a membranolytic mechanism of action.

Synthesis and antibacterial activity of antibiotic-functionalized graphite nanofibers

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Synthesis and antibacterial activity of antibiotic-functionalized graphite nanofibers<br />