<br/>Cardiolipins are ancient mitochondria-specific anionic phospholipids normally confined almost exclusively to the inner mitochondrial membrane. In this talk, I will present new concepts and data on the emerging role of cardiolipins in the interfacial signaling by dis-regulated mitochondria resulting from the collapse of the asymmetry, trans-membrane re-distribution, and externalization of cardiolipins to the organelle’s surface. I will describe two major pathways through which cardiolipins may accomplish the signaling function via their: i) recognition by an executionary protein of the autophageal machinery, LC3, causing mitophagy, and ii) oxidation catalyzed by an intermembrane space hemoprotein, cytochrome c, leading to apoptosis. Finally, I will discuss a new concept that interfacial cardiolipins and their oxidation/hydrolysis products constitute a rich communication language utilized by mitochondria of eukaryotic cells for diversified regulation of cell physiology and metabolism as well as for inter-cellular interactions.

Interfacial exposure, recognition, and signaling by nitochondrial cardiolipins

249th National Meeting (2015)

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