<i>The field of antibody engineering has evolved from simply plucking binders out of libraries to engineering molecules with industrial-grade expression, stability, solubility, and specificity.  For small molecules, the "Lipinski Rule of 5” provides a widely accepted rule of thumb for structural features consistent with successful drug development.  Is there a similar pattern in the values for biophysical properties of developable antibody drugs?   Analysis of a broad spectrum of features of a large sample of antibodies in commercial clinical development will be presented with an eye towards the emergence of such criteria for antibodies.</i>

Biophysical properties of antibody drugs: Predicting and engineering developability

249th National Meeting (2015)

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