The preparation and investigation into the antimicrobial activity of a wide variety of thiophenyl aryl sulfones through super acidic regioselective coupling of thiophene sulfonyl chlorides/arenes, by usage of trifluoromethanesulfonic acid is shown.The extent of the reaction was evaluated with a wide variety of aromatic substrates/aryl sulfonyl chlorides under superacidic Friedel-Crafts conditions. Literature QSAR parameters for the known antimicrobial action of diphenyl sulfones, were then comparitively optimized allowing directed synthesis of the thiophenyl aryl sulfone isosteres.

Triflic acid mediated thiophenyl sulfonylation of arenes and subsequent antimicrobial activity determination of thiophenyl aryl sulfones

249th National Meeting (2015)

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