The La Crosse Virus (LCV), which is transmitted by mosquitos, can cause serious problems especially when contracted by children. Some complications that can arise can range from a simple fever to encephalitis. We have data suggesting that a component of the supernatant of the genus <i>pseudomonas</i> may display antiviral activity against LCV. It is well known that pseudomonads produce phenazines. These phenazines show antibacterial and antifungal activity. We have an interest in investigating whether these phenazines are involved in the observed antiviral activity. Phenazines are redox-active compounds that can generate reactive oxygen species (ROS) that can have a potential toxic effect on bacteria and fungi. By synthesizing an array of phenazine compounds, we can analyze them against LCV and test their potential antiviral effects.

Potential antiviral effects of phenazine derivatives on the La Crosse virus

249th National Meeting (2015)

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