In this research, a process for creating control-release chloroquine by an oil-in-water emulsion method was developed. The aqueous phase was composed of a polyvinyl alcohol with octanol surfactant, and the organic phase consisted of base-form chloroquine with polycaprolactone in methylene chloride. Variables such as addition rate, stir time, container configuration, and amount of organic solvent were adjusted to optimize the shape and composition of the resultant microparticles. The products were filtered through stacked sieves to separate particles of consistent size. Elution profiles of chloroquine in solutions of varying pH were determined by HPLC analysis.

Developing controlled-release chloroquine

249th National Meeting (2015)

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