Sulfated saccharides mediate a myriad of physiological processes, including primary steps of bacterial and viral pathogenesis, tumor growth and progression, and angiogenesis. Out of the subset of bioactive. A well-studied lipopolysaccharide within this class of saccharides is Axinelloside A. Axinelloside A is a unique target for chemical synthesis due to its distinct structural features, and its potent inhibitory activity against human telomerase (IC<sub>50</sub> 2 mg/mL). In this communication we will present recent progress toward total synthesis of Axinelloside A and its analogs; specifically, we will discuss the application of dehydrative glycosylation method to preparation of truncated fragments of this highly sulfated lipopolysaccharide and the impact of sulfation on its biological activity.

Studies toward total synthesis of axinelloside A and its analogs

249th National Meeting (2015)

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