TYK2 is a member of the family of Janus kinases that are receptor-associated cytoplasmic tyrosine kinases with a central role in cytokine signaling.  TYK2 in particular is known to be a key mediator of IL12-and IL23-signaling, thus being implicated in innate lymphoid cell activation and diseases of chronic inflammation.  We will describe the structure- and property-based optimization of screening hits to highly potent and selective TYK2 inhibitors suitable for in vivo studies.  These studies revealed important information about the role of this kinase in pathway signaling. <br/>

Identification of selective TYK2 inhibitors and their role in IL12- and IL23-pathway signaling

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.