Current experimental evidence suggests that oxidative stress, or the overproduction of reactive oxygen species (ROS), plays a role in the appearance of numerous inflammatory diseases such as asthma, diabetic retinopathy, and atherosclerosis. The enzyme nicotinamide adenine disphosphonucleotide (NADPH) oxidase has been confirmed as the predominant source of ROS within endothelial cells, as well as in other cells that are affected by inflammatory processes. Previous studies have confirmed that apocynin and its analogs may be excellent inhibitors of NADPH oxidase, thus having great pharmaceutical value. The three-dimensional structures of these molecules will be studied for their potential active sites with NADPH oxidase via x-ray diffraction. A variety of new synthesis reactions, including the reduction of apocynin and diapocynin, are underway as well to discover new methods of making these prospective pharmaceuticals. Experiments are in progress and results will be presented.

Synthesis and recrystallization of diapocynin and its derivatives

249th National Meeting (2015)

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