The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. The nitro chalcone were prepared by aldol condensation using of mechanical agitation and environmentally friendly solvents with 72-73% yields in approximately 2 hours. The three structures were evaluated on biological activity at dose of 200 mg/Kg and they showed anti-inflammatory protective effect by both oral and intraperitoneal administration, this effect was time dependent.

Synthesis and anti-inflammatory activity of three nitro chalcones

249th National Meeting (2015)

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