Protein adsorption to biomaterial represents a key first step in many material-solution interactions. Quartz Crystal Microbalance with Dissipation (QCM-D) has emerged as a sensitive and rapid tool to study these interfacial phenomena. Herein we report the synthesis, characterization and protein adsorption profiles for several starch-containing hybrid polymers. The starch-based hybrids were synthesized by both graft-to and graft-through approach. A series of starch containing hybrid were synthesized (28%, 36%, 53% and 79%) and their protein adsorption characteristics were measured. Additionally, protein adsorption profiles of these amphiphilic graft copolymers were compared to relevant controls including polycaprolactone, PEG-g-polyurethane and urethane linked polyester (base polymer). In general, starch based hybrid polymers showed considerably lower protein adsorption compared to that of polycaprolactone acting as a control. At the same time, as the starch concentration in the hybrid increased from 28% to 53%, protein adsorption decreased significantly. These results show the versatility of starch as a biocompatible protein repellent surface modifier and advocate well for the future of polymeric material design.

Starch-containing hybrid polymers: Studying protein adsorption via quartz crystal nicrobalance with dissipation (QCM-D)

249th National Meeting (2015)

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