The ability of organotin polyethers derived from the anticoagulant dicumarol to inhibit a variety of human cancer cell lines was studied. The tested cell lines were the PC-3 prostate cell line, MDA MB-231 and MCF-7 breast cell lines, HT-29 colon cell line, and AsPC-1 and PANC-1 pancreatic cancer cell lines. EC<sub>50</sub> values were similar for the polymers compared with cisplatin. Thus, they exhibit a decent ability to inhibit the various cell lines. There does not appear to be a difference in the ability to inhibit growth for the two breast-associate cell lines. Also, they exhibit decent inhibition of the two pancreatic cancer cell lines as well as the cell lines of the other cancer-associated cells. The CI<sub>50</sub> values are similar employing either WI-38 or 3T3 cell as the standard. Thus, it is appropriate for this study to employ either in evaluation of the polymers to inhibit cell growth.

Initial study of the ability of organotin polyethers derived from the anticoagulant dicumarol to inhibit cancer cell lines

249th National Meeting (2015)

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