Teaching Medicinal Chemistry has come a long way from our use of large plastic lecture models, and continues to evolve. Every year there are about twenty new drug introductions, with at least a couple of them representing first-in-class medicines. How does one teach to prepare students for material that hasn't been discovered yet? We have developed a class exercise to encourage familiarity with the principles of hypothesis-driven structure-based drug design, which summarizes the tools required for understanding inevitable new discoveries. The number of drug receptor interactions known at atomic resolution has exploded since Kari Mullis invented PCR, most accessible on the protein data bank (pdb), which has open access freeware for visualization. We have developed class exercises which incorporate the pdb into real time visualization of drug receptor interactions in Med Chem classes at the introductory graduate and professional pharmacy levels, where we use the on-line resource in class. There are individual and team based learning components of the exercise. Its fun, bring your lap top or cell phone, because there's an app for that.

How to PDB: a class exercise for professional Pharmacy Med Chem

249th National Meeting (2015)

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