Peptidomimetics are synthetic oligomers that resemble the activities of peptides. Their advantages over peptides include high stability towards proteolysis and enormous chemical diversity. Over the past two decades, there have been extensive efforts to develop peptide mimics, such as beta-peptides, peptoids, D-peptides, <i>etc</i>. The research on peptidomimetics have led to many important applications in both medicinal and material science. In order to explore new functions, the discovery of peptidomimetics with novel frameworks is essential. Herein, we report the synthesis and evaluation of a new class of peptidomimetics, termed as γ-AApeptides. Studies of γ-AApeptides reveal that γ-AApeptides are highly resistant to proteolysis, and are highly amendable to chemical diversification. In addition, their unique biological activities and folding properties suggest that γ-AApeptides will be further explored to possess novel structures and functions so as to find applications in both medicinal and material science.

γ-AApeptides as a new class of peptidomimetics

249th National Meeting (2015)

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