α,β-Unsaturated carbonyl compounds, such as chalcones, show many biological activities that include cytotoxic anti-tumor activity, enzyme inhibition activity by reacting with sulfhydryl groups involved in different pathways that lead to cancer. However, apart from their useful biological activities, chalcones also show harmful biological effects on normal human cells for which they are highly neglected in drug development. The biological activity of α,β-unsaturated carbonyl compounds is mainly based on the their α,β-unsaturated carbonyl moiety, also called Michael system. Investigation of the reactivity of the Michael system with various aromatic ring substituents and their subsequent biological testing will allow for structure-activity relationship studies.<br/><br/>This research is directed towards the synthesis of chalcones with different aromatic ring substituents and study of their reactivity against thiol containing compounds.The influence of different aromatic ring substituents on the reactivity of chalcones is investigated and revealed by Nuclear Magnetic Resonance spectroscopy. The goal of this research is to synthesize and discover novel chalcones with no harmful effects on normal human cells.

Synthesis and kinetic investigation of differently substituted chalcones

249th National Meeting (2015)

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