Increasing targeting ability of drug delivery materials is pivotal to achieve high therapeutic efficacy of many drugs. Beyond achieving high drugs accumulation at the disease tissue, target specific intracellular delivery followed by a stimulus responsive release of drugs are critical to guarantee the optimal function of the drug with minimal toxic side effects. To achieve these requirements, we have designed a series of biodegradable semiconducting conjugated polymer nanoparticles (CPNs) by the self-assembly of conjugated polymers (CPs) containing both organelle specific targeting and a stimulus responsive functional groups for anti-cancer drugs release. In this presentation, synthesis of biodegradable CPs, side chain-dependent intracellular targeting, and controlled release of pro-drugs at the targeted organelles will be discussed. By combining the nanoparticles’ passive and active targeting ability, the intracellular targeting ability of CPNs will further improve the drug efficacy. Finally, the intrinsic fluorescent nature of CPNs will also provide tracking of the delivery events.

Conjugated polymer nanoparticles for intracellular organelle specific drug delivery

249th National Meeting (2015)

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