The development of sequence-controlled polymers is an important emerging topic in polymer science (Figure 1). Progress in that area of research has been particularly significant during the last five years. Indeed, innovative strategies for regulating comonomer sequence distribution in chain-growth and step-growth polymerizations have been reported. In addition, new polymerization pathways involving tailor-made soluble supports, macromolecular templates, and molecular machines have been described in the literature. In this lecture, I will summarize the advances that have been made and discuss the last hurdles that need to be overcome to achieve perfect sequence-regulation. This discussion will be illustrated by recent examples obtained in my laboratory. For example, the synthesis of monodisperse sequence-defined polymers using accelerated iterative protocols will be discussed in details.

Sequence-controlled polymerizations: The Holy Grail is near

249th National Meeting (2015)

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