A colloidal approach was used to produce magnetic nanocomposites (MNCs) composed of gold (Au) and iron oxides (Fe3O4, Fig. A).The as-prepared Au-Fe3O4 MNCs exhibited tunable fulorencence, in addition to the MNC being cost-effective to produce, with surface templaing flexibility, homogeneity in size and composition at the molecular level. The MNCs were engineered using a three-step procedure: (i) production of ultrafine Au-Fe3O4 MNPs with tunable size and architecture; (ii) formulation with traditional Indian medicine (tIm) to form a core-shelled structure (tIm@Au-Fe3O4, Fig. B); and iii) evaluation of MNC-core shell cytotoxicity against Chinese hamster ovarian cancer cell lines. The stiociometry (initial molar ratio of the Fe3+ and Fe2+ precursors) was maintained in the final MNCs, demonstrating control of dimension, composition and magnetism. In this present approach, the MNCs incorprated with tIm exhibit biocomptability and efficacy upon tIm release. In essence, the system exhibits “trojan horse” mode of activation and cell inhibition to enhance their biocompatibility as cancer theranostic agents. Other pharmacologic approaches using antitopoisomerase I inhibitor, such SN-38 can be similarily used to deliver on-target and inhibit cell division upon activation of external magent field (Fig. C).

Green synthesis of magnetic nanocomposites formulated with Indian medicine to perform cancer theranostic study

249th National Meeting (2015)

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