A binary cocrystal is a crystalline structure composed of two different compounds in a definite ratio. Our cocrystal design consists of one compound containing two hydrogen-bond donors in combination with a compound containing a single hydrogen-bond acceptor. The ten didonor compounds we have tested in this research consist of an aromatic core appended with a carboxylic acid and a phenol. We have investigated the ability of these compounds to form cocrystals with two different acceptor compounds: dibenzyl sulfoxide and triphenylphosphine oxide. A total of over 150 cocrystallization experiments were carried out and analyzed by infrared spectroscopy to identify the formation of cocrystals. HNMR was then used to determine the stoichiometry of any cocrystals that formed. In this poster the cocrystal design strategy, the experimental methods, and the analyses will be discussed along with applications in future work.

Investigation of the ability of dibenzyl sulfoxide and triphenylphosphine oxide to form cocrystals with carboxylic acids and phenols

249th National Meeting (2015)

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