The α-hydroxy acid moiety found in photoactive siderophores can be incorporated into organic compounds that mimic the strong binding affinity and photoactive properties of an iron-siderophore complex. A series of compounds that contain the α-hydroxy acid (AHA) in the tripodal amine structural motif has been synthesized. Varying the functional groups attached to the non-AHA arms of the tripodal amine allows for studies of metal complex structure, stability and photochemistry. New derivatizations of the AHA ligands are currently being synthesized, including α-hydroxy amides and α-thiol acids. The iron complexes of natural siderophores that contain α-hydroxy amides have photoactive properties. Using previously made AHA chelates, new α-hydroxy amide chelates are being synthesized, and the photochemistry of iron complexes with both sets of chelates will be studied.

Bioinspired α-hydroxy acid containing tripodal amine chelates and photoactivity of their metal complexes

250th National Meeting (2015)

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