Macro-porous graphene oxide (GO)/titanate nanowire scaffolds with desirable surface chemistry and tunable mechanical properties were prepared by electrochemical deposition of GO nanosheets on porous titanate nanowire scaffolds. The interconnected and porous structure of the GO/titanate nanowire scaffolds, originating from the titanate nanowire matrix, provided a large surface area for cellular attachment and migration and displayed a high compressive strength of about 81.1 MPa and a tunable Young’s modulus in the range of 12.41 to 40.98 GPa, which satisfies site-specific requirements for implantation. Surface chemistry of the scaffolds was tailored by the introduction of GO, which endowed the scaffolds flexibility in attaching and patterning bioactive groups (such as -OH, -COOH and -NH<sub>2</sub>).<i> In vitro</i> cell culture tests revealed that the GO/titanate nanowire scaffolds could be a promising biomaterial candidate, in particular the one containing -OH groups, which demonstrated improved cell viability, and proliferation, differentiation and osteogenic activities.

Graphene oxide–modified titanate nanowire scaffolds: Structural, mechanical, and biological properties

250th National Meeting (2015)

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