We have developed an improved route to trans-4-(boc-amino)-4-methylcyclohexanol (1) from inexpensive ethyl 4-oxocyclohexanecarboxylate (2). Hundreds of grams of 1 could be obtained from a single batch in 9 steps with an overall yield of 16% [figure1]. In the same manner, cis-4-(boc-amino)-4-methylcyclohexanol (7) can be produced efficienctly.

Improved synthesis of trans/cis-4-(boc-amino)-4-methyl cyclohexanol

250th National Meeting (2015)

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