FXYD5, also known as dysadherin, interacts with Na+/Na+ ATPase and alters its kinetics by increasing Vmax. It also is a cancer associated protein whose expression inhibits E-Cadherin and promotes metastasis. The abundance of FXYD5 correlates to progression of malignancies and survival. Silencing FXYD5 decreases cell motility, while overexpression stimulates it. The chemokine CCL2, also known as MCP-1, participates in monocyte recruitment during infection. Many tumors secrete CCL2 which attracts macrophages that promote tumor growth, angiogenesis, and metastasis. This study shows that FXYD5 expression strongly increases CCL2 secretion.

Cancer associated protein FXYD5 (dysadherin) may promote tumorgenicity by stimulating the secretion of the chemokine CCL2 (MCP-1)

250th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.