In multicomponent reactions (MCRs), three or more reactants combine in a sequential manner to produce a product in a highly selective fashion that retains the majority of the atoms of the starting materials. In an MCR, a product is assembled according to a cascade of elementary chemical reactions. Thus, there is a network of reaction equilibria, which all finally flow into an irreversible step yielding the final product. Such processes have great importance in organic as well as medicinal chemistry and constitute a challenge from academic and industrial view-points. These are highly efficient in diversity-oriented synthesis, especially to generate compound libraries for screening purposes. On the other hand, pyranopyrazole scaffold is an important pharmacophore that has not been explored in detail. An organocatalyzed green synthetic methodology leading to the synthesis of diversely substituted pyranopyrazoles has been developed. This one-pot four-component procedure is not only high-yielding but also satisfy most of the principles of green chemistry. This reaction may find application in the synthesis of biologically active pyranopyrazoles.

Organocatalyzed multicomponent synthesis of pyranopyrazoles: A green approach

250th National Meeting (2015)

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